Kenward, Michael G. (1987). A Method for Comparing Profiles of Repeated Measurements. Applied Statistics, Vol. 36, pp. 296-308. "Consider the following experiment on the control of intestinal paasites in cattle. During the grazing season, from spring to autumn, cattle can ingest roundworm larvae which have developed from eggs previously deposited on the pasture in the faeces of infected cattle. Once infected an animal is deprived of nutrients and its resistance to other disease is lowered, which in turn can greatly affect its growth. The monitoring of the effects of a treatment for the disease requires observations to be made throughout the grazing season. In an experiment to compare two methods, A and B say, for controlling the diseases, 60 animals were randomly assigned to treatment groups of size 30. The animals were put out to pasture at the start of the grazing season, the members of each group receiving one of the two treatments. The weight of each animal was then recorded 11 times to the nearest kilogram. The first 10 measurements were made at two-weekly intervals and the final measurement was made after a one-week interval. The esperimenter wishes to know if there is a difference in the between the groups in teh growth of the animals and, in particular, if such a difference exists, the time of measurement at which it first occurs. " Kenward (1987) cow data. "Table 1. Repeated measurements of weights (in kg) of calves from the trial on the control of intestinal parasites. " id G 0 14 28 42 56 70 84 98 112 126 133 1 A 233 224 245 258 271 287 287 287 290 293 297 2 A 231 238 260 273 290 300 311 313 317 321 326 3 A 232 237 245 265 285 298 304 319 317 334 329 4 A 239 246 268 288 308 309 327 324 327 336 341 5 A 215 216 239 264 282 299 307 321 328 332 337 6 A 236 226 242 255 263 277 290 299 300 308 310 7 A 219 229 246 265 279 292 299 299 298 300 290 8 A 231 245 270 292 302 321 322 334 323 337 337 9 A 230 228 243 255 272 276 277 289 289 300 303 10 A 232 240 247 263 275 286 294 302 308 319 326 11 A 234 237 259 289 311 324 342 347 355 368 368 12 A 237 235 258 263 282 304 318 327 336 349 353 13 A 229 234 254 276 294 315 323 341 346 352 357 14 A 220 227 248 273 290 308 322 326 330 342 343 15 A 232 241 255 276 293 309 310 330 326 329 330 16 A 210 225 242 260 272 277 273 295 292 305 306 17 A 229 241 252 265 274 285 303 308 315 328 328 18 A 204 198 217 233 251 258 272 283 279 295 298 19 A 220 221 236 260 274 295 300 301 310 318 316 20 A 233 234 250 268 280 298 308 319 318 336 333 21 A 234 234 254 274 294 306 318 334 343 349 350 22 A 200 207 217 238 252 267 284 282 282 284 288 23 A 220 213 229 252 254 273 293 289 294 292 298 24 A 225 239 254 269 289 308 313 324 327 347 344 25 A 236 245 257 271 294 307 317 327 328 328 325 26 A 231 231 237 261 274 285 291 301 307 315 320 27 A 208 211 238 254 267 287 306 312 320 337 338 28 A 232 248 261 285 292 307 312 323 318 328 329 29 A 233 241 252 273 301 316 332 336 339 348 345 30 A 221 219 231 251 270 272 287 294 292 292 299 31 B 210 215 230 244 259 266 277 292 292 290 264 32 B 230 240 258 277 277 293 300 323 327 340 343 33 B 226 233 248 277 297 313 322 340 354 365 362 34 B 233 239 253 277 292 310 318 333 336 353 338 35 B 238 241 262 282 300 314 319 331 338 348 338 36 B 225 228 237 261 271 288 300 316 319 333 330 37 B 224 225 239 257 268 290 304 313 310 318 318 38 B 237 241 255 276 293 307 312 336 336 344 328 39 B 237 224 234 239 256 266 276 300 302 293 269 40 B 233 239 259 283 294 313 320 347 348 362 352 41 B 217 222 235 256 267 285 295 317 315 308 301 42 B 228 223 246 266 277 287 300 312 308 328 333 43 B 241 247 268 290 309 323 336 348 359 372 370 44 B 221 221 240 253 273 282 292 307 306 317 318 45 B 217 220 235 259 262 276 284 305 303 315 317 46 B 214 221 237 256 271 283 287 314 316 320 298 47 B 224 231 241 256 265 283 295 314 313 328 334 48 B 200 203 221 236 248 262 276 294 291 311 310 49 B 238 232 252 268 285 298 303 320 324 320 327 50 B 230 222 243 253 268 284 290 316 314 330 330 51 B 217 224 242 265 284 302 309 324 328 338 334 52 B 209 209 221 238 256 267 281 295 301 309 289 53 B 224 227 245 267 279 294 312 328 329 297 297 54 B 230 231 244 261 272 283 294 318 320 333 338 55 B 216 218 223 243 259 270 270 290 301 314 297 56 B 231 239 254 276 294 304 317 335 333 319 307 57 B 207 216 228 255 275 285 296 314 319 330 330 58 B 227 236 251 264 276 287 297 315 309 313 294 59 B 221 232 251 274 284 295 300 323 319 333 322 60 B 233 238 254 266 282 294 295 310 320 327 326