### Biostatistics 251 Multivariate Biostatistics

**Spring 2014.**

Prerequisites: Satisfactory performance in Biostat 250a and b. Biostat 251 is a mathematical introduction to multivariate statistical methods for biostatistics doctoral students. Doctoral students from statistics, education and psychology have successfully completed the course. This is neither applied nor a substitute for Biostat 406. We move very quickly, and we cover many different methods. If you have taken Biostat 100a in the past 3 years, you do not belong in this class.

**Spring 2014 - Robert Weiss**

**News & Announcements:**

- Web Pages updated for 2014...
- Class Schedule & Syllabus/Course Info updated for 2014 ...

**Class Schedule, Email Address, and Office Hours:**

Event | Time | Day | Room |
---|---|---|---|

Lecture | 10:00 - 11:50 | Monday, Wednesday | 41-268 CHS |

Discussion | 11:00 - 11:50 | Friday (usually will not meet) | 71-257 CHS |

Prof | Robert Weiss | robweiss@ucla.edu | 51-269 CHS |

MidQuarter | 10:00 - 11:50 | Monday May 12 | 41-268 CHS |

Final | 3:00 - 6:00pm | Tuesday June 10 | 41-268 CHS |

Office Hours | 12:00 - 1:00 | Monday, Wednesday | 51-269 CHS |

**Syllabus and Textbook**

2014 Syllabus and Course Information

Lecture Notes. Zipped directory of complete set of lecture notes. Password protected. Bring to class!

Pictures of Students Relaxing with Our Textbook

**2014 Homework** Note: Homework due dates are weekly every Wednesday.

- Possible papers to present (PPP) (Presentations 8th week).
- Single Index Models (Jia & Weiss; Weiss, Jia & Suchard) GW M1
- Multivariate nested longitudinal counts (Zhu & Weiss; Supplement) DC W2
- IOU Processes (Taylor, Cumberland & Sy; Sy, Taylor & Cumberland) QL W1
- t Models for Longitudinal Data (Lange, Little & Taylor)
- Latent Process Model for MV longitudinal (Proust, Jacqmin-Gadda, Taylor, Ganiayre & Commenges) MF M2
- An Analysis of Paediatric CD4 Counts for Acquired Immune Deficiency Syndrome Using Flexible Random Curves (Shi, Weiss & Taylor); Principal component models for sparse functional data (Hastie, James and Sugar); Nonparametric Mixed Effects Models for Unequally Sampled Noisy Curves (Rice & Wu)

2014 Homework.

- Homework Number 1. Due Apr 16.
- Homework Number 2. Due Apr 23.
- Homework Number 3. Due Apr 30.
- Homework Number 4. Due May 7. [Updated 5/2/2014, fixed error in problem 1(d) formula at end of line 2. Re-uploaded at 9:44pm.]
- Homework Number 5. Due May 14.
- Homework Number 6. Due May 28.
- Homework Number 7. Due May 28.
- Homework Number 8. Due June 4.

**Useful Links**

- Modeling Longitudinal Data Text Home Page
- Biostat 236 Repeated Measures
- R Project Home Page
- On line Proc Mixed documentation from SAS Institute
- UCLA ATS's SAS resources

**BSI Data Set**

**Lab 8: Longitudinal data plots in R**

After downloading the data and the code, you should have two .RData extension files. Drag and drop them on your R command window to load them into R. Any questions, let me know.

**R commands and files to produce all figures from chapter 2 in my book** Requires all the data sets and files that follow.